Glad you cleared that up, I was fixing to check to see if Topo 5 came on a DVD, I didn't think it did.
Topo 5.0 did have a DVD option
.....I just confirmed it.
You don't have to uninstall the data if in fact that's what you installed. Just install the program, and then in the Map File tab, click on Add and then Data Locations. You should be able to add the folder on your HD that you installed the Region data to, and it will use that data. Make sure you go to the DeLorme website and download and run all updates for the program before you start using it.
You should also consider getting Topo 7.0 when it comes out this fall. 5.0 will be 4 years old and very out of date, program and data wise.